New Publications
The authors examined whether using different item sets to estimate PROPr yielded systematic differences in scores using cross-sectional data from a sample of 199 cancer patients. They varied the PROMIS Pain Interference item set, including 4 items from the PROMIS-29, 2 items from the PROPr technical report, and 10 items from a custom short form. While PROMIS Pain Interference and PROPr scores did differ at the individual level, they did not differ meaningfully on average.
The authors examined the psychometric properties of the PROMIS parent proxy pediatric sleep measures (sleep disturbance, sleep-related impairment) in a nationally representative sample of children and adolescents aged 5-16 in Spain. Overall, the authors identified strong psychometric properties, including sex- and age-related invariance, and provided age-based norms.
This single-center retrospective study matched three cohorts of patients seen by a hand surgeon (carpal tunnel syndrome, trigger finger, and distal radius fracture) with/without high anxiety (PROMIS Anxiety T-score ≥70) based on primary diagnosis, sex, race, age, and surgeon. Matched patients with and without high anxiety were offered surgery at a similar rate, but those with high anxiety were less likely to undergo surgery and were more likely to have postoperative complications. Sentiment analysis of surgeon office notes identified more frequent (but still limited) acknowledgment of the patient’s emotional state in those with high anxiety.
Huang Y, You J, Wang Q, Wen W, Yuan C. Trajectory and predictors of post-stroke depression among patients with newly diagnosed stroke: A prospective longitudinal study. J Stroke Cerebrovasc Dis. 2024 Oct 15:108092. doi: 10.1016/j.jstrokecerebrovasdis.2024.108092. Epub ahead of print. PMID: 39419243.
Huang et al. examined longitudinal trajectories of depression (measured using PROMIS Depression 8a) in 119 stroke patients with three time points of measurement (baseline, 3 months, and 6 months) after discharge from their initial stroke treatment. A linear growth curve model with two classes was selected: Class 1 (~40% of the sample) started out with moderate levels and decreased over time, and Class 2 (~60% of the sample) started out with high levels and increased over time. Membership in the Class 2 trajectory was associated with lower cognitive function but not social ability or physical function (all assessed using PROMIS measures).
Aminpour E, Holzer KJ, Frumkin M, Rodebaugh TL, Jones C, Haroutounian S, Fritz BA. Preoperative predictors of acute postoperative anxiety and depression using ecological momentary assessments: a secondary analysis of a single-centre prospective observational study. Br J Anaesth. 2024 Oct 24:S0007-0912(24)00569-5. doi: 10.1016/j.bja.2024.08.035. Epub ahead of print. PMID: 39455306.
Aminpour et al. leveraged items from PROMIS anxiety and depression short forms for ecological momentary assessment (three time points of measurement daily). Specific items (versus the entire short forms) were used to increase feasibility of assessment. Dynamic structural equation modeling was used to examine person-level changes in anxiety and depression over the initial 30 days after major surgery. Worse preoperative PROMIS anxiety and depression scores (versus self-reported history of the condition) were more closely associated with worsening postoperative anxiety or depression.
Northrop A, Christofferson A, Umashankar S, Melisko M, Castillo P, Brown T, Heditsian D, Brain S, Simmons C, Hieken T, Ruddy KJ, Mainor C, Afghahi A, Tevis S, Blaes A, Kang I, Asare A, Esserman L, Hershman DL, Basu A. Implementation and impact of an electronic patient reported outcomes system in a phase II multi-site adaptive platform clinical trial for early-stage breast cancer. J Am Med Inform Assoc. 2024 Aug 19:ocae190. doi: 10.1093/jamia/ocae190. Epub ahead of print. PMID: 39158353.
Northrop et al. describe the multi-site implementation of electronic PROs to collect adverse event and quality of life data from participants in a platform clinical trial for breast cancer. Longitudinal scheduling of questionnaires was automated, with measures including PROMIS and PRO-CTCAE instruments. Beyond technical integration, there was a focus on multi-stakeholder collaboration, including patient advocates who were included throughout the implementation. Additionally, personalized engagement was provided to sites, with monitoring allowing targeting of strategies to the lowest-performing sites to improve completion rates. Completion of the screening questionnaire was associated with increased likelihood of completing follow-up questionnaires, but there were no demographic differences overall in completion rates.